Clinical Trials Target Children with PKD

One clinical trial will look at the effects of blood pressure medications on PKD kidneys, while the other evaluates the risk factors for kidney failure and how loss of kidney function can affect heart disease and growth.

The first study, to take place at The Children’s Hospital in Denver, will study how blood pressure medications can slow renal cyst growth over a five-year period in children and young adults, ages 4 to 21, with the dominant form of PKD. Results of this study could significantly impact the standard of care for management of ADPKD for patients in this age group. All expenses, including study-related medications, a home blood pressure machine, travel costs to and from Denver (including one parent to accompany minor children) and lab and radiology testing, will be provided. For more information, contact Dr. Melissa Cadnapaphornchai toll-free at 877-765-9297 or pkd.nurse@uchsc.edu.

The second study, with sites in both Boston and Kansas City, will evaluate children with chronic kidney disease, including those with the dominant and recessive forms of PKD, ADPKD and ARPKD. The study will determine the risk factors for kidney function decline and define how kidney failure impacts neurocognitive functions and behaviors, such as cardiovascular disease and growth failure. Enrollment has already begun. For more information, click here.

Study sites and contact information are as follows: