Standard Grants: Year 1, $75,000 Each
Oregon Health and Science University in Portland, OR:
Estrogen metabolites and experimental polycystic kidney disease
PKD Information at Oregon Health and Science University
Brigham and Women's Hospital in Boston, MA:
Characterization of the role of the Nek8 kinase in development
PKD Information at Brigham and Women's Hospital
Harvard Medical School in Boston, MA:
TAZ as a possible substrate of Nek kinases
PKD Information at Harvard
University of Technology in Aachen, Germany:
Characterization of the PKHD1 gene and genotype-phenotype studies in autosomal recessive polycystic kidney disease (ARPKD)
Fondazione-Telethon Institute of Genetics and Medicine in Naples, Italy:
Elucidation of the role of OFD1 in renal cystic disease
PKD Information at Fondazione-Telethon Institute of Genetics
Indiana University in Indianapolis, IN:
Delivery of a human artificial chromosome harboring a PKD1 transgene into renal epithelial cells
PKD Information at Indiana University
Beth Israel Deaconess Medical Center in Boston, MA:
Stem cell therapy for polycystic kidney disease
PKD Information at Beth Israel Deaconess Medical Center
Stowers Institute for Medical Research in Kansas City, MO:
Histone deacetylases (HDACs) and Autosomal Dominant Polycystic Kidney Disease (ADPKD)
PKD Information at Stowers
University of Michigan in Ann Arbor, MI:
Regulation of ciliary trafficking by RP2
PKD Information at University of Michigan
Centre National de la Recherche Scientifique (C.N.R.S.) in Roscoff, France:
Roscovitine-derived pharmacological inhibitors of cyclin-dependent kinases: optimization and characterization for PKD therapeutic application
PKD Information at C.N.R.S.
Leiden University Medical Center in Leiden, The Netherlands:
The role of TGFB-signaling in the progression of polycystic kidney disease
PKD Information at Leiden University Medical Center
Texas A&M in University College Station, TX:
Identification of effectors for the IFT27, an intraflagellar transport (IFT) particle protein functioning in the cell cycle
PKD Information at Texas A&M
The Mount Sinai School of Medicine in New York, NY:
Biomechanical transduction of gene transcription in renal tubular epithelia
PKD Information at Mount Sinai
Yale University in New Haven, CT:
Angiogenesis and progression of liver cysts in ADPKD
PKD Information at Yale
University of Iowa in Iowa City, IA:
Molecular mechanism of renal deciliation and cystogenesis
PKD Information at University of Iowa
Fellowships: Year 1, $50,000 Each
University of Massachusetts Medical School in Worchester, MA:
Primary role for the centrosome in cilia formation and ciliopathies
PKD Information at University of Massachusetts Medical School
Johns Hopkins University School of Medicine in Baltimore, MD:
Using induced PKD1 inactivation and network modeling strategies to identify gene networks responsible for post-natal kidney maturation and cystogenesis
PKD Information at Johns Hopkins
University of Kansas Medical Center, The Kidney Institute in Kansas City, KS:
Role of 14-3-3 and A-kinase anchoring proteins on the cAMP-dependent B-Raf signaling and proliferation of ADPKD cells
PKD Information at University of Kansas Medical Center
Children's Hospital of Boston in Boston, MA:
Regulation of pkd2 expression by a3ß1 integrin
PKD Information at Children's Hospital
Cincinnati Children's Hospital Medical Center in Cincinnati, OH:
The role of primary cilia in regulating mammalian target of rapamycin signaling
PKD Information at Cincinnati Children's Hospital Medical Center
Brigham and Women's Hospital in Boston, MA:
Molecular mechanism of renal cystogenesis in ADPKD
PKD Information at Brigham and Women's Hospital
Young Investigator Career Development Awards: Year 1, $65,000 Each
The Johns Hopkins University School of Medicine in Baltimore, MD:
Polycystin signaling in Drosophila melanogaster
PKD Information at Johns Hopkins
The Penn State University in University Park, PA:
The roles for Inturned in kidney development and PKD pathogenesis
PKD Information at Penn State
Brigham and Women's Hospital in Boston, MA:
Molecular mechanisms of the autosomal recessive polycystic kidney disease
PKD Information at Brigham and Women's Hospital
Translational Grants: Year 1
Yale University in New Haven, CT
Discovery of New Polycystic Kidney Disease Drugs Using a Novel, Validated Bioassay in High Throughput Screens
University Hospital Zurich in Zurich, Switzerland
Clinical Proof-of-Concept Trial to Assess the Therapeutic Effect of Sirolimus in Patients with Autosomal Dominant Polycystic Kidney Disease: SUISSE ADPKD Study [NCT00346918]
Standard Grants: Year 2, $75,000 Each
Texas Tech University Health Sciences Center in Lubbock, TX:
The effect of inhibition of IL-8 and b-catenin on the evolution of in vivo and in vitro models of ADPKD
PKD Information at Texas Tech
Yale University School of Medicine in New Haven, CT:
Mechanism of polycystic liver disease in Hhex mutant mice
PKD Information at Yale
Fondazione Centro San Rafelle del Monte Tabor in Milan, Italy:
The role of polycystins in renal development
PKD Information at Fondazione
University of Texas Southwestern Medical Center in Dallas, TX:
The role of Wnt9b signaling in PKD
PKD Information at University of Texas Southwestern
Swiss Federal Institute of Technology in Lausanna, Switzerland:
The role of Bicc in PKD and cilia signaling
PKD Information at Swiss Federal Insititute of Technology
Yale University School of Medicine in New Haven, CT:
Molecular investigation of polycystin-2 regulation
PKD Information at Yale
Yale University School of Medicine in New Haven, CT:
Pathogenesis of congenital hepatic fibrosis and biliary cyst formation in ARPKD
PKD Information at Yale
Johns Hopkins School of Medicine in Baltimore, MD:
Novel interacting proteins of the PC1 plat domain
PKD Information at Johns Hopkins
University of Alabama at Birmingham in Birmingham, AL:
Identification of PKD markers: Transcriptome-profiling based approach
PKD Information at UAB
University of Sheffield School of Medicine in Sheffield, England:
The role of peroxisome proliferator activated receptor (PPAR)-gamma agonists in the progression of cystic and vascular phenotypes in ADPKD
PKD Information at University of Sheffield
Medical College of Wisconsin in Wauwatosa, WI:
The role of 20-HETE in polycystic kidney disease
PKD Informaiton at Medical College of Wisconsin
Johns Hopkins School of Medicine in Baltimore, MD:
Discovering extracellular ligands of polycystin-1
PKD Information at Johns Hopkins
Yale University School of Medicine in New Haven, CT:
The role of pontin in cilia assembly and cyst formation in zebrafish
PKD Information at Yale
University of California at San Francisco in San Francisco, CA:
CFTR-based therapy for PKD
PKD Information at UCSF
Purdue University in Indianapolis, IN:
Structural analysis of polycystin-2 cytoplasmic domain
PKD Information at Purdue
University of Alabama at Birmingham in Birmingham, AL:
Cilia and cAMP in cystic disease
PKD Information at UAB
USC Keck School of Medicine in Los Angeles, CA:
Role of claudin-7 in chloride an fluid secretion in PKD
PKD Information at USC
Fellowships: Year 2, $50,000
University of Texas MD Anderson Cancer Center in Smithville, TX:
Polycystin-1 regulation of the TSC2 tumor suppressor tuberin
PKD Information at University of Texas MD
Yale University School of Medicine in New Haven, CT:
The biflagellate Chlamydomonas as a model cell for studying PKD2 function
PKD Information at Yale
University of Texas in Galveston, TX:
Genome-wide combinatoril analysis of HNF-1b target genes in kidney
PKD Information at University of Texas Galveston
Hokkaido University School of Medicine in Hokkaido, Japan:
Molecular genetic basis of kidney and liver cyst formation in ADPLD
PKD Information at Hokkaido University
Massacusetts General Hospital in Boston, MA:
The role of HNF-1b in renal development and PKD, and isolation of novel PKD drugs using zebrafish as a disease model
PKD Information at Massachusetts General
Beth Israel Hospital, Harvard Medical School in Boston, MA:
Role of ATP in shear stress-induced Ca signaling in human kidney cells
PKD Information at Harvard
Core Grants: Year 2, $44,000
Mayo Clinic in Rochester, MN:
ADPKD Gene Mutation Registry
PKD Information at Mayo
Collaborative Grants: Year 2, $37,500 Each
Institute of Medical Genetics, Cardiff University in Cardiff, UK:
Investigating the relationship between tuberous sclerosis and PKD using mouse models
PKD Information at Institute of Medical Genetics
Fox Chase Cancer Center in Philadelphia, PA:
Roles of tuberin (TSC2) and Rheb in cystic kidney disease
PKD Information at Fox Chase Cancer Center
University of Texas MD Anderson Cancer Center in Houston, TX:
C-SRC regulation of the functional PKD-1 TSC2 interation
PKD Information at University of Texas MD
Translational Grants: Year 2, $100,000 Each
Mayo Clinic in Rochester, MN:
Evaluation and treatment of chronic pain in ADPKD
PKD Information at Mayo
Mayo Clinic in Rochester, MN:
Treatment of polycystic liver disease
PKD Information at Mayo
Mario Negri Institute in Bergamo, Italy:
Effect of long acting somatostatin on disease progression in ADPKD: A long-term three year follow-up study
PKD Information at Mario Negri Institute