Research GrantsResearch Grants

The PKD Foundation aims to support the development of clinical interventions for the treatment of polycystic kidney disease (PKD). Since its inception, we have invested almost $40 million in more than 550 research, clinical and scientific grants, fellowships and scientific meetings.

 

2016 Grant recipients

In 2016, we awarded research grants to 15 outstanding PKD researchers for a total investment of $2.4 million over the next two years. The Research Grant Program will fund critical research to increase understanding of the genetic and pathological processes involved in PKD and to accelerate the development of potential therapies for PKD patients.

 

Read on to learn about current and past research projects.

 

Other funding opportunities:

Baltimore PKD Center – Pilot and Feasibility Program

 

2016 Grant recipients

Dr. Vincent H. Gattone Research Award for the top-rated grant proposal
Funded in partnership with friends/family in memory of Sophie St. Aubin and in honor of Sophia Shapiro

Katherine M. Dell, M.D.Magnetic Resonance Fingerprinting (MRF) to Assess ARPKD Kidney and Liver Disease

Katherine M. Dell, M.D.
Case Western University

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The Dan Larson Research Grant

David Beier, M.D., Ph.D.Screening for Modifiers of PKD Severity Using ENU Mutagenesis

David Beier, M.D., Ph.D.
Seattle Children's Research Institute

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The Eileen Creamer O'Neill Award

Tetyana Masyuk, Ph.D.Deregulated Cholangiocyte Autophagy: A New Target for Polycystic Liver Disease

Tetyana Masyuk, Ph.D.
Mayo Clinic

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Sorin Fedeles, M.S., Ph.D.Examining the Role of XBP1 in the Pathogenesis of Protein Folding-associated Polycystic Kidney Disorders

Sorin Fedeles, M.S., Ph.D.
Yale School of Medicine 

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Brunella Franco, M.D.The Role of Autophagy in Renal Cystogenesis

Brunella Franco, M.D.
Telethon Institute of Genetics and Medicine

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Benjamin Freedman, Ph.D.Modeling Human PKD Cystogenesis With Pluripotent Stem Cells

Benjamin Freedman, Ph.D.
University of Washington

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Edward Inscho, Ph.D.Renal Vascular Function in ARPKD

Edward Inscho, Ph.D.
University of Alabama at Birmingham

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Timothy Kline, Ph.D.Development of a Computer-aided Decision Support System for PKD

Timothy Kline, Ph.D.
Mayo Clinic

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Stephen Parnell, Ph.D.Polycystin-1 Mediated Cyst Regression

Stephen Parnell, Ph.D.
University of Kansas Medical Center

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Dr. York PeiGenetic Modifiers of Severe Polycystic Liver Disease (Grant co-funded by the PKD Foundation of Canada)

York Pei, M.D.
Toronto General Hospital

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Dr, Feng QianRole of Fibrocystin/Polyductin in Health and ARPKD

Feng Qian, Ph.D.
University of Maryland School of Medicine

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Edward Skolnik, M.D.A Novel Screen to Identify Kinases That Are Activated in PKD Kidneys

Edward Skolnik, M.D.
New York University Medical Center

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Dr. Zhaoxia SunVascular Integrity in Zebrafish PKD Models

Zhaoxia Sun, Ph.D.
Yale University

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Bradley Yoder, Ph.D.Injury Response Mediated Pathogenesis in Ciliopathies

Bradley Yoder, Ph.D.
University of Alabama at Birmingham

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Xia Zhou, M.D., Ph.D.Functional Roles of DNMT1 in Autosomal Dominant Polycystic Kidney Disease

Xia Zhou, M.D., Ph.D.
University of Kansas Medical Center

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2014 Grant recipients

Read a summary of each grant's progress report
For summaries of the projects grant recipients are conducting, please click here or read below.

Dr. Vincent H. Gattone Research Award for the Top-Rated Grant Proposal
Funded by The Carlo and Micol Schejola Foundation

Advancing HSP90 Inhibitors Towards Clinical Trials for ADPKD

Dr. Erica GolemisErica Golemis, Ph.D.
The Research Institute of Fox Chase Cancer Center
(Therapy Development)

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International Awardees

The Eileen Creamer O'Neill Award

Targeting Glucose Metabolism in PKD: A Preclinical Proof-of-Concept Study*

Dr. Alessandra BolettaAlessandra Boletta, Ph.D.
Fondazione Centro San Raffaele
(Therapy Development)

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Health Care Utilization and Costs of ADPKD

Dr. York PeiYork Pei, M.D.
University of Toronto General Hospital
 

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Effects of Genetic and Pharmacological Ablation (Deletion) of KCNN4 on Disease Progression in Two Orthologous Mouse Models of PKD

Dr. Marie TrudelMarie Trudel, Ph.D.
Institut de Recherches Cliniques de Montreal
(Therapy Development)

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United States Awardees

The Jean A. Bost Award

Role of CFTR and NKCC1 in PKD

Dr. Jim CalvetJames Calvet, Ph.D.
University of Kansas Medical Center
(Discovery Research)

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The Haggard Family Award

Preclinical Assessment of MCP-1/CCR2 Inhibition as Treatment for ADPKD

Dr. Timothy Fields and Dr. Katherine Swenson-FieldsTimothy Fields, M.D., Ph.D., and Katherine Swenson-Fields, Ph.D.
University of Kansas Medical Center
(Therapy Development)

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Funded in Partnership with Friends and Family of Infant Sophie St. Aubin

Investigation of the Biological Basis and Therapeutic Effect of Anti-tumor Drug 11beta-dichloro on PKD*

Dr. Rachel GallagherAnna Rachel Gallagher, Ph.D.
Yale University
(Therapy Development)

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The Mrs. Pamela Whitcomb Larsen Award

The Role of Beta-catenin as Signal Integrator in PKD

Dr. Jordan KreidbergJordan Kreidberg, M.D., Ph.D.
Boston Children's Hospital
(Discovery Research)

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Role of Tulp3 and the Hedgehog Pathway in PKD

Dr. Karel Liem, Jr.Karel Liem, Jr., M.D., Ph.D.
Yale University
(Discovery Research)

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The Effects of Genetic Reactivation of Functional Polycystins on Progression of PKD*

ResearchMing Ma, Ph.D.
Yale University
(Discovery Research)

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Funded in partnership with KidneyTexas, Inc.

Role of miR-17~92 in the Pathogenesis of PKD

Dr. Vishal PatelVishal Patel, M.D.
University of Texas Southwestern Medical Center
(Discovery Research)

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Unifying Cystogenic Mechanism of ADPKD and ARPKD*

Dr, Feng QianFeng Qian, Ph.D.
University of Maryland Medical Center: Division of Nephrology
(Discovery Research)

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HDAC Inhibitor Mediated Kidney Cyst Reduction

Dr. Zhaoxia SunZhaoxia Sun, Ph.D.
Yale University
(Discovery Research)

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The Rosemary M. Peppet Award

Phosphodiesterase/cAMP Signaling in Renal Cystogenesis (Cyst Formation) in Zebrafish

Dr. Caroline SussmanCaroline Sussman, Ph.D.
Mayo Clinic
(Discovery Research)

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The Dan Larson Research Grant

In Vivo Analysis of Cilia Mechanosensation in the Kidney

Dr. Brad YoderBradley Yoder, Ph.D.
University of Alabama at Birmingham
(Discovery Research)

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Rachel GallagherRead what the PKD Foundation research grant does for Dr. Rachel Gallagher's work to end PKD.

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©2016, PKD Foundation ·The PKD Foundation is a 501 (c)(3), 509 (a)(1) public charity.

©2016, PKD Foundation ·The PKD Foundation is a 501 (c)(3), 509 (a)(1) public charity.