Standard Grants: Year 2, $60,000 Each
Mayo Clinic College of Medicine in Rochester, MN: Christopher J. Ward, MB, ChB, PhD
Analysis of the interaction of Polycystin-1 positive exosome-like vesicles with primary cilium
Massachusetts General Hospital in Charlstown, MA: Iain A. Drummond, PhD
Polycystin regulation of ER/Golgi calcium and its role in matrix assembly and secretion
Mayo Clinic College of Medicine in Rochester, MN: Vicente E. Torres, MD, PhD
Role of secretion in polycystic kidney disease
Fellowships: Year 2, $45,000 Each
Brandeis University in Waltham, MA: David B. Doroquez, PhD
Role of intercellular trafficking in C.elegans ciliated sensory neurons: a model for transport in ciliated kidney epithelia
PKD Researcher Information at Brandeis University
Young Investigator Career Development Awards: Year 2, $52,000 Each
Mayo Clinic College of Medicine in Rochester, MN: Jinghua Hu, PhD
Exploring the function of the ciliary ATP synthase in polycystin signaling
Young Investigator Career Development Awards: Year 3, $52,000 Each
The Penn State University in University Park, PA: Aimin Liu, PhD
The roles for Inturned in kidney development and PKD pathogenesis
This study will investigate in renal tubules a protein Intu that is involved in cilia formation and the regulation of cell polarity in other systems.
Brigham and Women's Hospital in Boston, MA: Shixuan Wang, MD, PhD
Molecular mechanisms of the autosomal recessive polycystic kidney disease
ARPKD is caused by mutations in the PKHD1 gene which makes a protein called polyductin. This study will examine the functions of polyductin in cell replication and its interaction with nuclear proteins.
Core Grants: Year 3
Indiana University in Indianapolis, IN: Vicente H. Gattone, II, PhD
Electron microscopy core facility for PKD researchers
Mayo Clinic College of Medicine in Rochester, MN: Peter C. Harris, PhD
ADPKD gene mutation registry